According to researchers from King’s College London, a drug called Tideglusib can stimulate the teeth to self-repair, thus eliminating the need for dental fillings.
Tideglusib in other cases is used to treat dementia, but a team of scientists found that in laboratory mice, it can stimulate cells in the tooth pulp to heal small holes. The holes in the teeth of mice were treated using a biodegradable sponge impregnated with a medicine and inserted into the cavity.
The study, published in the “Scientific Reports”, showed that such treatment leads to “full, effective natural recovery”. Tideglusib stimulated the activity of cell cells in the tooth pulp, which led to the regeneration of holes of 0.13 millimeter in mice.
According to Professor Paul Sharp, one of the researchers: “The sponge is biodegradable, this is the key thing.
“The space occupied by the sponge is filled with minerals, as the dentin regenerates, so you do not have anything that could fail in the future.”
The scientific team will now try to determine whether their treatment can fix large holes. Sharpe said that this type of dental treatment can soon be commercialized.
“I do not think this is a long term, it’s a rather low-hanging fruit in regenerative medicine, and I hope that within three to five years it will be commercially available.”
Although the field of regenerative medicine is often a concern for cancer because it induces cells to quickly separate to repair damage, this drug has already been tested in even larger numbers in patients with dementia and was safe.
According to Professor Sharpe, “security work has been carried out in much higher concentrations, so we hope that we will win.”
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